Cart
sales@molnova.com
Home - Products - Proteasome/Ubiquitin - E2 - UBE2M-DCN1 inhibitor 52

UBE2M-DCN1 inhibitor 52

CAS No. 2089293-14-9

UBE2M-DCN1 inhibitor 52( —— )

Catalog No. M13265 CAS No. 2089293-14-9

UBE2M-DCN1 inhibitor 52 is a highly potent inhibitor of DCN1-UBE2M protein-protein interaction with IC50 of 60 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    UBE2M-DCN1 inhibitor 52
  • Note
    Research use only, not for human use.
  • Brief Description
    UBE2M-DCN1 inhibitor 52 is a highly potent inhibitor of DCN1-UBE2M protein-protein interaction with IC50 of 60 nM.
  • Description
    UBE2M-DCN1 inhibitor 52 is a highly potent inhibitor of DCN1-UBE2M protein-protein interaction with IC50 of 60 nM, inhibits cullin neddylation in pulse-chase NEDD8 transfer assay with EC50 of 80 nM; binds to DCN1 and selectively reduce steady-state levels of neddylated CUL1 and CUL3 in a squamous cell carcinoma cell line, inhibits DCN1 but not DCN3 stimulated NEDD8 transfer from UBE2F to the cullins.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    E2
  • Recptor
    E2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2089293-14-9
  • Formula Weight
    447.546
  • Molecular Formula
    C25H32F3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    1-Benzyl-1-(1-(pentan-2-yl)piperidin-4-yl)-3-(3-(trifluoromethyl)-phenyl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hammill JT, et al. J Med Chem. 2018 Apr 12;61(7):2680-2693.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • C25-140

    C25-140 is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6.

  • NAcM-OPT

    NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM in TR-FRET assays.

  • TZ9

    A novel selective inhibitor of Rad6 ubiquitin conjugating enzyme.

Sign In Join Free